I have been operated 4 times in last 12 years for nasal inverted pappiloma endophytic type Recurrence rate are high Do homeopathy have solutions for this. Sir am 26 year old mbbs student.. I have a single wart on my index fingure.. What medication will i follow as i dont want to go for a surgery i need homeopathic medication from you.
I have gental warts over my penus and surrounding area , right now they are not very big and about 8 in numbers. I am having immune booster tablets and vitamin b12 now days and using Paimt which my Dr prescribe me. Please click the link to understand Scientific basis on homeopathy. Legal Disclaimer -None of the medicines mentioned including services , mentioned at Drhomeo. We do not claim to cure any disease which is considered' incurable ' on the basis of scientific facts by modern medicine.
Homeopathy at DrHomeo. Home Online Treatment Dr. Vikas Sharma MD 53 Comments. Write To Dr. Sharma Cancel reply Write to Dr. Sharma and get a reply on how homeopathy can help you in treating your disease condition. Comments Jayakrishnan says:. October 27, at am. Rand says:. August 21, at am. Hi Dr Sharma I think I definitely have HPV virus, I have female genitalia wart, now I have a painful mouth ulcer and very a, this is exasperated by the fact that I have recently started smoking again which has brought my immunity down.
Ahava says:. March 22, at pm. Donna Stone says:. January 15, at am. Anita says:. July 9, at pm. Get cryo surgery done and take lots of multivitam i did this treatment i also had.
Sarat Misra says:. January 12, at pm. Pankaj kumar says:. December 24, at am. Maggie says:. December 15, at pm. Can oral thuja help with asymptomatic HPV? High risk HPV. November 1, at am. September 3, at pm. Honey says:. September 14, at pm. Omer says:. May 22, at am. Dr Rahul says:. May 9, at am.
Hello Sir, Greetings. I hope and wish that you and all your near-dear ones are safe during this global catastrophe. Present complaints are as follows — 1. Nails of feet are splitting into two but not from the centre It is requested to guide and advise.
Ram mondal says:. February 13, at am. Kitty Phetla says:. October 21, at pm. Doc if I have hpv 16 and hpv18 does this mean I have cervical cancer? It is kitty again.
Jagadeesh says:. May 13, at am. I have genital warts on Penis and scrotum please provide medicine. Ritu Rathi says:. September 18, at pm. Mahipal Singh Negi says:. August 22, at am. Dear Dr. Sharma, i am suffering from HPV around my private parts. Regards Mahipal Negi. Mg Tin Mg says:. June 18, at pm. Vivek says:. June 8, at am. Biopsy tissue samples for viral DNA extraction were collected on the 0 th day for PCR confirmation of canine papillomavirus infection.
Five microliters of PCR product obtained after amplification was run on 1. Visualization of a band of base pair bp size amplified product was the confirmation for the presence of canine papillomavirus nucleic acid in the tissue sample.
Mann—Whitney U-test was used to analyze the difference in the clinical score observed between the two groups. Wilcoxon test was used to compare the clinical success rate of each treatment group with the examination days. Clinical examination of dogs revealed almost normal physiological activity body temperature, heart rate, respiration rate, and conjunctival mucous membrane with the exception of a few animals showed mild-to-moderate anorexia because of oral papillomatous lesions.
Results of the complete blood count and serum chemistry of all dogs were within the normal range data not shown. Examination of the oral cavity revealed numerous papillomatous growths protruding from the surface of oral mucous membranes of infected dogs.
Warts were grayish-white, pink, and black in color due to pigmentation. Grossly, lesions were characterized by hard verrucose, proliferative, and hyperkeratotic usually variable sized, multiple, sessile, and also single and cluster Figure The papilloma had smooth and rough, jagged, and crumbling surfaces which can be removed but causes bleeding.
Papillomatous lesions had narrow base with a wide projection on the mucosal surface. Cut sections revealed multiple fingers like projections. A tentative diagnosis of COP was made based on clinical examination.
It should be noted that there was no associated dermatological abnormality in all the dogs except oral papilloma lesions. In Group B, variable-sized proliferative papillomas in the oral cavity, lips and mucocutaneous junction on day 0 of treatment. In Group A, none of the dogs treated with placebo showed regression of oral lesion on 7 days of post-treatment.
In Group B, treatment with homeopathic drug combination resulted in complete regression of oral lesion in 7 days 4 of 8 dogs. On the 10 th day of post-treatment, none of the dogs in Group A showed regression but in Group B, three more dogs showed complete regression. On the 15 th day of post-treatment, still, none of the dogs in Group A showed regression of oral lesion but in Group B, the remaining one dog showed complete regression. On contrary to the treatment group, the placebo treatment group showed regression from the 90 th day onward.
Shortly, three dogs showed complete regression of papilloma around 90 th day and two dogs on th day after post-placebo treatment. Remaining three dogs in the placebo group showed regression around th day.
Moderate to severe infiltrations of keratohyalin granules were observed in the cytoplasm of proliferating epithelial cells. The presence of intranuclear inclusions in the keratinocytes was noticed in a few sections. Other associated findings noticed were parakeratosis and eosinophilic cytoplasmic inclusions koilocytes. Tissue sections of dogs from 5 th day of homeopathic treatment revealed reduction in hyperplastic changes, development of uniform cells without anaplastic changes, neovascularization in between fibrous stroma of core, moderate to severe diffuse infiltration of the mononuclear cells in the connective tissue stroma, loss of keratin layer as a whole, and a focal area of keratinization with nucleus in stratum corneum were noticed suggesting regeneration Figure In Group B, at day 0 of treatment, hyperplasia of stratum corneum with severe infiltrations of keratohyaline granules in the cytoplasm of proliferating epithelial cells.
In Group B, hyperplasia of stratum corneum of stratified squamous epithelium with the central fibrous core on day 0 of treatment. In group B, 5 th day of homeopathic treatment showed reduced hyperplasia, neovascularization, parakeratosis with severe infiltration of mononuclear cells in connective tissue stroma.
PCR analysis revealed the association of canine papillomavirus in all dogs with papillomatous oral lesions. PCR amplification of canine papillomavirus DNA isolated from papillomatous tissue from dogs showed an amplicon size of bp Figure Polymerase chain reaction PCR amplification of canine papillomavirus DNA isolated from papillomatous tissue from dogs.
PCR product of base pair product confirms positive amplification. L1: Nontemplate negative control; L2-L7: Oral papilloma samples. On day 0, the clinical scores of both groups were the same. In Group A, lesion score for papilloma remained the same 4. In contrast, lesion score in Group B was only 2. Further, no lesion observed on day 15 in Group B.
Comparison of clinical scores between Group A control and Group B homeopathic group during days of the experiment. Despite autoregression, treating oral papilloma cases are very crucial because of the physical difficulty the animal faces while taking food, restriction from social interaction with other dogs, anorexia, drooling, halitosis, bleeding, secondary bacterial infections, and purulent discharge near papillomas [ 4 ].
Various therapeutic regimes were used to alleviate COP. Injectable interferon directly stimulates the immune system thereby helps to resolve warts.
Non or semi-invasive approaches such as surgical excision, debulking of exophytic lesion with electro or radiosurgery or by sharp resection, electrocautery, cryotherapy, crushing of warts to stimulate immunity [ 9 ], crushing laser or cryosurgery [ 8 ], photodynamic therapy [ 34 ], and spontaneous regression and autoimmune therapy [ 35 ] were also reported.
COP can be treated with combination of inactivated autogenous vaccine, chemotherapy, and application of T. Treatment such as surgical removal and vaccination may increase the size of residual warts and prolong the course of the disease. Surgical removal becomes difficult when the extend of papilloma lesion is more [ 32 ].
The relationship between clinical resolution and surgical intervention is difficult to determine due to the frequent spontaneous regression of this papilloma. Anesthesia is required for surgical removal of warts which make the surgical way of treating papilloma riskier in addition to special care and high cost. Laser and cryotherapy are used in the ablation of papilloma but multiple treatments are generally needed [ 38 ]. Autogenous vaccine and immune modulation drugs such as levamisole and thiabendazole are used but proof for their efficiency is lacking [ 7 ].
Systemic or local chemotherapy drugs such as vincristine, vinblastine, cyclophosphamide, methotrexate, chlorambucil, and doxorobucin lead to inefficient or controversial results in the majority of papilloma cases, with longer duration of the treatment period and varying degrees of success [ 3 , 34 ].
Homeopathy is an alternative therapy available at affordable prices and becoming increasingly popular in human medicine in developing countries that have negligible adverse effect with the use [ 39 ]. Agnihotri et al. These homeopathy drugs have been used in human medicine for long. None of the homeopathic drugs used in this experiment have been proven to cause any side effect. It has been already proved that Thuja T. Sulfur 30 promotes healthy skin condition which heals damaged skin, Graphites 30 is a powerful anti-psoric and commonly used against eruptions in the skin and mucosal surfaces in humans and Psorinum 30 also has anti-psoric activity [ 41 ].
Sulfur was used to treat pruritus associated with atopic dermatitis in dogs [ 14 ]. Graphites were used to treat hypertrophic burn scars successfully in humans [ 42 ] and canine demodicosis [ 43 ]. Combination of Sulfur, Psorinum, and Graphites with other homeopathic drugs was used in dogs for treating various skin conditions such as seborrhea, pruritus, allergic dermatitis, and Hot Dog Syndrome [ 44 ].
Sulfur, Psorinum, and Graphite in combination are used to treat canine mange [ 45 ]. Madrewar and Glencross [ 22 ] have stated the use of different combinations of homeopathy drugs against all kinds of dermatitis, ringworm, wet or dry eczema and to remove warts of all types on any part of the animal body.
Further, no adverse effect was observed during the course and after the treatment. No recurrence of papilloma was observed during the follow-up period of 12 months in all treated dogs. A combination of homeopathic drugs is a novel approach for treating canine oral papilloma and further studies are needed to elucidate the use of homeopathic combination as a veterinary oncological therapeutics and to explore the mechanism of action of these homeopathic drugs in ameliorating oral papilloma.
PAAR designed the experiment, sorted dogs into two groups and wrote most parts of the manuscript. SS and RS performed clinical evaluation and analysis. SSab performed randomization, blinding, and literature search. All authors read and approved the final version of the manuscript. We sincerely thank the Department of Animal Husbandry, Villupuram, for providing the necessary facilities and support to conduct this experiment.
This study did not receive any external funding. Veterinary World remains neutral with regard to jurisdictional claims in published institutional affiliation. National Center for Biotechnology Information , U. Journal List Vet World v. Vet World. Published online Jan Asok Kumar , 3 S. Sangeetha , 4 R. Shanmugapriya , 4 and S. Sabithabanu 4. Albert Arockia Raj. Asok Kumar. Author information Article notes Copyright and License information Disclaimer.
Corresponding author: P. Albert Arockia Raj, e-mail: moc. Received Aug 4; Accepted Dec Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.
This article has been cited by other articles in PMC. Abstract Aim: A study was conducted to evaluate the ameliorative potential of homeopathic drugs in combination Sulfur 30C, Thuja 30C, Graphites 30C, and Psorinum 30C in 16 dogs affected with oral papillomatosis which was not undergone any previous treatment.
Materials and Methods: Dogs affected with oral papillomatosis, which have not undergone any initial treatment and fed with a regular diet. Conclusion: The current study proves that the combination of homeopathy drugs aids in fastening the regression of canine oral papilloma and proved to be safe and cost-effective.
Keywords: Graphites, homeopathy, oral papillomatosis, Psorinum, Sulfur, Thuja. Introduction Papilloma is a benign, exophytic, neoplastic proliferation of squamous epithelium caused by infection with papillomavirus; a non-enveloped double-stranded DNA virus which has a tropism for mucous membrane and skin [ 1 ]. Source of dogs and obtaining owner consent for experimentation The study was performed at Veterinary Dispensary, Radhapuram, Villupuram, India, between January 1, , and January 1, Table 1 Details of dogs that were used in the experimental study.
Breed Sex Age in months Group 1. Nondescript Male 9 Group A 2. Nondescript Male 5 3 Labrador Female 8 4. Nondescript Female 5 5. German shepherd Male 6 6. Nondescript Male 5 7. Doberman Male 9 8. Nondescript Male 3 9.
Labrador Female 9 Group B Nondescript Male 5 Clinical evaluation in both groups of dogs was performed by the same investigator throughout the period of study 12 months.
Dogs were clinically scored for oral lesions on days 0, 5, 7, 10, 15, 20, 25, 30, 45, 60, 90, , and after initiation of treatment. Oral papillomatous lesions regressed in the homeopathic group between 7 and 15 days, whereas regression of papilloma in the placebo group occurred between 90 and days.
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